Widest mod selection
No competitor offers a wider selection of modified oligos, including fluorescent
dyes and quenchers, non-fluorescent mods, and wobbles.
Superior quality
We offer several purity options with stringent quality control for every modified
oligo.
High capacity
A wide range of synthesis scales are possible, from 50 nmol to 10 µmol and above,
with uniformly high quality.
Reliable service
Our highly automated systems, with reliable human backup, ensure fast turnaround
times.
HPSF® Purity
HPSF purification is a high-performance, high-throughput purification technique
available on oligos with the following modifications: 5’ Phosphate, 5’ Amino C6,
5’ Biotin-TEG, and standard IUB wobbles.
QuickLC™
QuickLC purification is a proprietary purification process that offers purity levels
of 85% and above—equal to or greater than the levels obtained by HPLC purification.
QuickLC purification is available on oligos with the following modifications: 5’
6-FAM, 5’ Phosphate, 5’ Amino C6, 5’ Biotin-TEG, and standard IUB wobbles
Turn Around Time
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Scale
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Salt Free
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HPSF
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QuickLC
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HPLC
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PAGE
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50 nmol
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2
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2
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2
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5
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7
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0.2 µmol
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2
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2
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2
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5
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7
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1 µmol
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2
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2
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2
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5
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7
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10 µmol
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3
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NA
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NA
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5
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NA
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>10 µmol
|
inquire
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inquire
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inquire
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inquire
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inquire
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|
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Modifications
Fluorescent dyes
For fluorescence in situ hybridization (FISH) and RNA in situ hybridization
(RISH).
Non-fluorescent mods for immobilization and/or detection
Including amino groups, biotin, and digoxygenin.
Phosphorylation
For oligo ligation.
Phosphothioate and 2’-O-methyl RNA
To confer oligo stability against nuclease activity for antisense studies.
Defined wobbles
A defined mixture of nucleotides can be incorporated at a specific position within
the oligo. For cloning orthologous or paralogous genes.
Other modifications
For a complete listing of modifications, click the link in the navigation to the
left. Or call Customer Service at
1 (800) 688-2248 or 1 (256) 704-8200 to inquire about additional modifications.
Purification options
See a description of the
purification methods available as well as our recommendations for specific applications.
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